Archive of Medical Research

Cyclic nitroxides inhibit the toxicity of nitric oxide-derived oxidants: mechanisms and implications.
The substantial therapeutic potential of tempol (4-hydroxy-2,2,6,6-tetramethyl-1-piperidinyloxy) and related cyclic nitroxides as antioxidants has stimulated innumerous studies of their reactions with reactive oxygen species. In comparison, reactions of nitroxides with nitric oxide-derived oxidants have been less frequently investigated. Nevertheless, this is […]

COL18A1 is highly expressed during human adipocyte differentiation and the SNP c.1136C > T in its \”frizzled\” motif is associated with obesity in diabetes type 2 patients.
Collagen XVIII can generate two fragments, NC11-728 containing a frizzled motif which possibly acts in Wnt signaling and Endostatin, which is cleaved from the NC1 and […]