Cytotoxic-Antineoplastic Derivatives of Prenyl-1,2-naphthohydroquinone.
Cytotoxic-Antineoplastic Derivatives of Prenyl-1,2-naphthohydroquinone.
Several new prenyl-1,2-naphthohydroquinone derivatives have been prepared by chemical modifications of Diels-Alder products which were obtained from cycloaddition of alpha-myrcene to 1,2-benzoquinone and then evaluated in vitro for their cytotoxic activity against A-549 lung carcinoma, HT-29 colon carcinoma, and MB-231 breast adeno-carcinoma culture cells. Most of them exhibited GI(50) values in the […]