[Fanconi anemia–genotoxic stress and senescence of hematopoietic stem cells]
Fanconi anemia (FA) is a genetically heterogeneous inherited disorder characterized by progressive bone marrow failure, development of hematopoietic and solid malignancies and genomic instability. 13 FA proteins, identified to date, closely cooperate with familial breast cancer susceptibility proteins such as BRCA2 and PALB2, thereby […]
[Paroxysmal nocturnal hemoglobinuria (PNH)]
Paroxysmal nocturnal hemoglobinuria is an acquired hematopoietic stem cell disorder. The most common clinical manifestations of PNH include intravascular hemolysis, venous thrombosis, and bone marrow failure. Hematopoietic stems cells with mutant PIG-A are present in normal marrow, but they are not noticed because they have no advantage under normal circumstances. In […]
[Critical role of phosphatidylserine in hemolysis due to red blood cell enzyme/membrane defects]
The life span of human red blood cells (RBCs) is approximately for 120 days, and finally destroyed in reticuloendothelial systems. In pathological conditions, RBCs fall into premature death, i.e. hemolysis. Recent studies have unveiled that abnormal RBCs affected by either […]
[Contemporary problems of occupational otorhinolaryngologic diseases: topical problems, some solutions and prospects]
The author presents contemporary structure of occupational otorhinolaryngologic morbidity reflecting prospective directions of advances in occupational otorhinolaryngology.
[The prevalence of anemia in Japan]
The frequency of anemia in Japan is statistically higher than that of foreign countries. Especially, Japanese females frequently fall ill with iron deficiency anemia(IDA) because of decreased intake of iron. Secondary anemia is of the second-highest frequency. While primary hematological disorders account for only a small fraction […]
[Calcium antagonists in the preoperative preparation of pregnant women with gestosis]
Differential preoperative preparation of pregnant women with gestosis, which is aimed at eliminating dysfunction of the universal secondary calcium messenger and preventing further disorders caused by calcium antagonists, is accompanied by positive changes in the basic links of development of the general […]
[Pregnancy in the context of general adaptation syndrome]
Based on their own findings and the data available in the literature on pregnancy including that complicated by gestosis, the authors consider these conditions in the context of Selye\’s general adaptation syndrome. They identify its basic links (the autonomic nervous and cardiovascular systems) the function […]
[Current approaches to spontaneous labor pain relief]
The authors have compared various modes of spontaneous labor. Prolonged epidural infusion of naropine in combination with fentanyl has been found to cause a less motor block and therefore it may be used in the late first-to-second period of labor. Adequate analgesia ensures a smooth course […]
[Clinical features of tuberculous pleurisy in viral hepatitis and HIV infection at penitentiaries]
In 1999 to 2005, the penitentiaries of Saint Petersburg and the Leningrad Region saw a drastic (almost 30-fold) increase in the number of patients with tuberculous pleurisy concurrent with viral hepatitis and HIV infection. The convicts with concomitant stages IVa, […]
[Determination of nutrition elements in Yak milk powder by atomic absorption spectrometry]
In the present paper, orthogonal design test was planed by changing cinefaction temperature, cinefaction time, and the concentration of hydrochloric acid. Yak milk powder and milk powder were digested by dry method. The contents of elements Ca, Mg, Fe, Cu, Zn, […]