Secretion of mouse growth hormone by transduced primary human keratinocytes: prospects for an animal model of cutaneous gene therapy
BACKGROUND: Keratinocytes are a very attractive vehicle for ex vivo gene transfer and systemic delivery because proteins secreted by these cells may reach the circulation via a mechanism that mimics the natural process. METHODS: An efficient retroviral […]
Influence of ozone concentration and temperature on ultra-fine particle and gaseous volatile organic compound formations generated during the ozone-initiated reactions with emitted terpenes from a car air freshener.
Experiments were conducted to identify the emissions from the car air freshener and to identify the formation of ultra-fine particles and secondary gaseous compounds during the ozone-initiated oxidations […]
The -149C>T SNP within the DeltaDNMT3B gene, is not associated with early disease onset in hereditary non-polyposis colorectal cancer.
Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominantly inherited syndrome caused by germline mutations in mismatch repair (MMR) genes. HNPCC patients have a lifetime risk of 80% of developing colorectal cancer (CRC); however […]
Thermal behavior, specific heat capacity and adiabatic time-to-explosion of G(FOX-7).
[H(2)NC(NH(2))(2)](+)(FOX-7)(-)-G(FOX-7) was prepared by mixing FOX-7 and guanidinium chloride solution in potassium hydroxide solution. Its thermal decomposition was studied under the non-isothermal conditions with DSC and TG/DTG methods. The apparent activation energy (E) and pre-exponential constant (A) of the two exothermic decomposition stages […]
Signaling via CNS cannabinoid receptors.
Because of the prominent psychoactive effects of cannabis and its preparations, much research has focused on the actions of cannabinoids, the primary psychoactive components of cannabis, on neuronal function. A convergence of research has identified (1) cannabinoid receptors, (2) endogenous compounds that activate these receptors (endocannabinoids), and (3) […]
T3-mediated expression of PGC-1alpha via a far upstream located thyroid hormone response element.
Thyroid hormone (T3) has a profound influence on normal development, differentiation and metabolism. T3 induces complex gene expression patterns raises the question of how these expression patterns might be regulated. Since the transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) […]
Partial cloning of CB1 cDNA and CB1 mRNA changes in stress responses in the Solea solea.
Endogenous cannabinoids, through the CB1 receptor, are involved in the control of several functions including stress responses. The aim of this study was to investigate the presence of cannabinoid receptor CB1 in the sole ovary by partial […]
Reflections on \’plant neurobiology\’
Plant neurobiology, a new and developing area in the plant sciences, is a meeting place for scientists concerned with exploring how plants perceive signs within their environment and convert them into internal electro-chemical (\’plant neurobiological\’) signals. These signals, in turn, permit rapid modifications of physiology and development that help […]
Latest Technologic and Surgical Developments in Using InterStimtrade mark Therapy for Sacral Neuromodulation: Impact on Treatment Success and Safety.
OBJECTIVES: This article accompanies a \”surgery in motion\” DVD on sacral neuromodulation (SNM) with InterStimtrade mark Therapy, which visualizes the implantation of the InterStim II system. The article describes the technical and surgical developments […]
Electrochemical treatment of aqueous wastes containing pyrogallol by BDD-anodic oxidation.
In this work, the electrochemical oxidation of pyrogallol (1,2,3-trihydroxybenzene) on boron-doped diamond anodes has been studied. The voltammetric results showed that pyrogallol oxidation takes place in the same potential region as that of phenol where the supporting electrolyte is stable. Synthetic wastewaters containing […]