No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer’s disease.
No association of DAPK1 and ABCA2 SNPs on chromosome 9 with Alzheimer\’s disease.
Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer\’s disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation.
Minster RL, Dekosky ST, Kamboh MI.
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA 15261, United States.